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KMID : 0377619620030010041
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Korean Jungang Medical Journal
1962 Volume.3 No. 1 p.41 ~ p.49
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Experimental Study on Longitudinal Bone Growth Stimulation
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Ahn Hwa-Yong
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Abstract
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In the orthopedic field, there have been many studies ´on the correction of inequality of leg length caused by various factors. The results of such experimental studies in the past were so variable and uncertain, that no method is widely accepted as a means of universal bone growth stimulation.
The Korean red pepper (Capsicum Annuum), which is used frequently in Korea as an important daily condiment, is known to be a local stimulant resulting, in hyperemia in the local tissue applied. The vascular hyperemia or stasis, moreover, in the region of bone growth has long been considered, to cause acceleration of the growth rate of long bone. For this viewpoint, we have. attempted to promote leg growth by the insertion of Capsicine (ether abstract of Capsicum Annuum( (C18H27NO3) mixed with paraffin into the metaphysis adjacent to the. upper tibial epiphysis in rabbits.
Forty-five young growing rabbits, four to : six weeks old, weighing about 350 gm are used in this, experiment. The animals are divided into Group I and Group II. In Group I the animals were subjected, to one operation, and in Group II the surgery was repeated on the same site two weeks after the first operation. These two groups are further divided into subgroups respectively: first, second, and third group each, thus making a total of six, groups of the animals.
In the first subgroups, surgical trauma alone was applied to the upper metaphysis of the left tibia in the close vicinity of the epiphyseal plate. The surgical trauma consisted of cortical fenestration and curettement of cancellous bone, thus making a small bony cavity in the metaphysis. After completion of the procedures, the cancellous bone and cortical window were replaced.
In the second subgroups in addition to the surgical trauma mentioned above, 75 mg. of paraffin was inserted into bony cavity.
In the third subgroups, same amount of Capsicine-Paraffin Mixture was inserted.
The animals of each subgroup, were sacrificed at the end of two, four and eight weeks after the last operation to obtain the actual value of measurement of both femora and tibiae.
RESULTS
The results of this experiment are as follows;
(1) No effect on longitudinal bone growth of the tibia was seen where the surgical trauma alone had been applied. (a-total of 13 rabbits in the combined first subgroups of Groups I and II.
(2) An average 0.83 mm. growth stimulation was obtained in six of the ten animals, where surgical trauma , and paraffin insertion had been done. These re the combined second subgroups of Groups I and II.
(3) An average 0.94mm of growth stimulation was noted in sixteen of the total twenty two animals where the surgical trauma and Capsicine-Paraffin Mixture had been inserted, (the combined third subgroups of Groups I and In two of the twenty-two animals, a minimal degree of growth retardation in the experimented tibiae was noted.
(4) It seems that the effect, of growth stimulation was larger in the third subgroups (with Capsicne-Paraffin) compared with that of the second subgroups (Paraffin only).
(5) Also the effect of growth stimulation appears to be larger in the Group II(two operations) animals in comparison with that of the Group I (one operation only). Fifty-six per cent, of the Group I animals showed, growth stimulation, averaging 0.82mm. In Group II eighty-one per cent of the total number showed growth stimulation with an average of 0.98mm.
CONCLUSION
From the results of this experiment, it is concluded, (1) that both Paraffin and Capsicine has an effect of bone growth stimulation of the long bones, (2) that there is a tendency of larger effect when the Capsicine-Paraffine Mixture was inserted than with Paraffin alone, and (3) that repeated surgery on the same site after a proper interval produces more pronounced effect on the stimulation of bone growth than in the case of single surgery.
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